H2N2V1, Main, Exploration, bibRecord, 000B96

Variability in transmissibility of the 2009 H1N1 pandemic in Canadian communities

Identifieur interne : 000B96 ( Main/Exploration ); précédent : 000B95; suivant : 000B97

Variability in transmissibility of the 2009 H1N1 pandemic in Canadian communities

Auteurs : Luiz C. Mostaço-Guidolin [Canada] ; Amy Greer [Canada] ; Beate Sander [Canada] ; Jianhong Wu [Canada] ; Seyed M. Moghadas [Canada]

Source :

BMC Research Notes [ 1756-0500 ] ; 2011.

RBID : PMC:3278401

Abstract

Background

The prevalence and severity of the 2009 H1N1 pandemic appeared to vary significantly across populations and geographic regions. We sought to investigate the variability in transmissibility of H1N1 pandemic in different health regions (including urban centres and remote, isolated communities) in the province of Manitoba, Canada.

Methods

The Richards model was used to fit to the daily number of laboratory-confirmed cases and estimate transmissibility (referred to as the basic reproduction number, R₀), doubling times, and turning points of outbreaks in both spring and fall waves of the H1N1 pandemic in several health regions.

Results

We observed considerable variation in R₀estimates ranging from 1.55 to 2.24, with confidence intervals ranging from 1.45 to 2.88, for an average generation time of 2.9 days, and shorter doubling times in some remote and isolated communities compared to urban centres, suggesting a more rapid spread of disease in these communities during the first wave. For the second wave, R_e, the effective reproduction number, is estimated to be lower for remote and isolated communities; however, outbreaks appear to have been driven by somewhat higher transmissibility in urban centres.

Conclusions

There was considerable geographic variation in transmissibility of the 2009 pandemic outbreaks. While highlighting the importance of estimating R₀for informing health responses, the findings indicate that projecting the transmissibility for large-scale epidemics may not faithfully characterize the early spread of disease in remote and isolated communities.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278401

DOI: 10.1186/1756-0500-4-537
PubMed: 22166307
PubMed Central: 3278401

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The prevalence and severity of the 2009 H1N1 pandemic appeared to vary significantly across populations and geographic regions. We sought to investigate the variability in transmissibility of H1N1 pandemic in different health regions (including urban centres and remote, isolated communities) in the province of Manitoba, Canada.</p>
</sec>
<sec><title>Methods</title>
<p>The Richards model was used to fit to the daily number of laboratory-confirmed cases and estimate transmissibility (referred to as the basic reproduction number, <italic>R</italic>
<sub>0</sub>
), doubling times, and turning points of outbreaks in both spring and fall waves of the H1N1 pandemic in several health regions.</p>
</sec>
<sec><title>Results</title>
<p>We observed considerable variation in <italic>R</italic>
<sub>0 </sub>
estimates ranging from 1.55 to 2.24, with confidence intervals ranging from 1.45 to 2.88, for an average generation time of 2.9 days, and shorter doubling times in some remote and isolated communities compared to urban centres, suggesting a more rapid spread of disease in these communities during the first wave. For the second wave, <italic>R<sub>e</sub>
</italic>
, the effective reproduction number, is estimated to be lower for remote and isolated communities; however, outbreaks appear to have been driven by somewhat higher transmissibility in urban centres.</p>
</sec>
<sec><title>Conclusions</title>
<p>There was considerable geographic variation in transmissibility of the 2009 pandemic outbreaks. While highlighting the importance of estimating <italic>R</italic>
<sub>0 </sub>
for informing health responses, the findings indicate that projecting the transmissibility for large-scale epidemics may not faithfully characterize the early spread of disease in remote and isolated communities.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zarychanski, R" uniqKey="Zarychanski R">R Zarychanski</name>
</author>
<author><name sortKey="Stuart, Tl" uniqKey="Stuart T">TL Stuart</name>
</author>
<author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name>
</author>
<author><name sortKey="Doucette, S" uniqKey="Doucette S">S Doucette</name>
</author>
<author><name sortKey="Elliott, L" uniqKey="Elliott L">L Elliott</name>
</author>
<author><name sortKey="Kettner, J" uniqKey="Kettner J">J Kettner</name>
</author>
<author><name sortKey="Plummer, F" uniqKey="Plummer F">F Plummer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kondro, W" uniqKey="Kondro W">W Kondro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Campbell, A" uniqKey="Campbell A">A Campbell</name>
</author>
<author><name sortKey="Rodin, R" uniqKey="Rodin R">R Rodin</name>
</author>
<author><name sortKey="Kropp, R" uniqKey="Kropp R">R Kropp</name>
</author>
<author><name sortKey="Mao, Y" uniqKey="Mao Y">Y Mao</name>
</author>
<author><name sortKey="Hong, Z" uniqKey="Hong Z">Z Hong</name>
</author>
<author><name sortKey="Vachon, J" uniqKey="Vachon J">J Vachon</name>
</author>
<author><name sortKey="Spika, J" uniqKey="Spika J">J Spika</name>
</author>
<author><name sortKey="Pelletier, L" uniqKey="Pelletier L">L Pelletier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="To, K" uniqKey="To K">K To</name>
</author>
<author><name sortKey="Wong, S" uniqKey="Wong S">S Wong</name>
</author>
<author><name sortKey="Li, I" uniqKey="Li I">I Li</name>
</author>
<author><name sortKey="Hung, I" uniqKey="Hung I">I Hung</name>
</author>
<author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name>
</author>
<author><name sortKey="Woo, P" uniqKey="Woo P">P Woo</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bautista, E" uniqKey="Bautista E">E Bautista</name>
</author>
<author><name sortKey="Chotpitayasunondh, T" uniqKey="Chotpitayasunondh T">T Chotpitayasunondh</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Harper, Sa" uniqKey="Harper S">Sa Harper</name>
</author>
<author><name sortKey="Shaw, M" uniqKey="Shaw M">M Shaw</name>
</author>
<author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name>
</author>
<author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Kettner, Jd" uniqKey="Kettner J">JD Kettner</name>
</author>
<author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name>
</author>
<author><name sortKey="Lim, M" uniqKey="Lim M">M Lim</name>
</author>
<author><name sortKey="Shindo, N" uniqKey="Shindo N">N Shindo</name>
</author>
<author><name sortKey="Penn, C" uniqKey="Penn C">C Penn</name>
</author>
<author><name sortKey="Nicholson, Kg" uniqKey="Nicholson K">KG Nicholson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="La Ruche, G" uniqKey="La Ruche G">G La Ruche</name>
</author>
<author><name sortKey="Tarantola, A" uniqKey="Tarantola A">A Tarantola</name>
</author>
<author><name sortKey="Barboza, P" uniqKey="Barboza P">P Barboza</name>
</author>
<author><name sortKey="Vaillant, L" uniqKey="Vaillant L">L Vaillant</name>
</author>
<author><name sortKey="Gueguen, J" uniqKey="Gueguen J">J Gueguen</name>
</author>
<author><name sortKey="Gastellu Etchegorry, M" uniqKey="Gastellu Etchegorry M">M Gastellu-Etchegorry</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Heesterbeek, Od" uniqKey="Heesterbeek O">OD Heesterbeek</name>
</author>
<author><name sortKey="P, Ja" uniqKey="P J">JA P</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Hanage, Wp" uniqKey="Hanage W">WP Hanage</name>
</author>
<author><name sortKey="Van Kerkhove, Md" uniqKey="Van Kerkhove M">MD Van Kerkhove</name>
</author>
<author><name sortKey="Hollingsworth, Td" uniqKey="Hollingsworth T">TD Hollingsworth</name>
</author>
<author><name sortKey="Griffin, J" uniqKey="Griffin J">J Griffin</name>
</author>
<author><name sortKey="Baggaley, Rf" uniqKey="Baggaley R">RF Baggaley</name>
</author>
<author><name sortKey="Jenkins, He" uniqKey="Jenkins H">HE Jenkins</name>
</author>
<author><name sortKey="Lyons, Ej" uniqKey="Lyons E">EJ Lyons</name>
</author>
<author><name sortKey="Jombart, T" uniqKey="Jombart T">T Jombart</name>
</author>
<author><name sortKey="Hinsley, Wr" uniqKey="Hinsley W">WR Hinsley</name>
</author>
<author><name sortKey="Grassly, Nc" uniqKey="Grassly N">NC Grassly</name>
</author>
<author><name sortKey="Balloux, F" uniqKey="Balloux F">F Balloux</name>
</author>
<author><name sortKey="Ghani, Ac" uniqKey="Ghani A">AC Ghani</name>
</author>
<author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name>
</author>
<author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name>
</author>
<author><name sortKey="Pybus, Og" uniqKey="Pybus O">OG Pybus</name>
</author>
<author><name sortKey="Lopez Gatell, H" uniqKey="Lopez Gatell H">H Lopez-Gatell</name>
</author>
<author><name sortKey="Alpuche Aranda, Cm" uniqKey="Alpuche Aranda C">CM Alpuche-Aranda</name>
</author>
<author><name sortKey="Chapela, Ib" uniqKey="Chapela I">IB Chapela</name>
</author>
<author><name sortKey="Zavala, Ep" uniqKey="Zavala E">EP Zavala</name>
</author>
<author><name sortKey="Guevara, Dme" uniqKey="Guevara D">DME Guevara</name>
</author>
<author><name sortKey="Checchi, F" uniqKey="Checchi F">F Checchi</name>
</author>
<author><name sortKey="Garcia, E" uniqKey="Garcia E">E Garcia</name>
</author>
<author><name sortKey="Hugonnet, S" uniqKey="Hugonnet S">S Hugonnet</name>
</author>
<author><name sortKey="Roth, C" uniqKey="Roth C">C Roth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pourbohloul, B" uniqKey="Pourbohloul B">B Pourbohloul</name>
</author>
<author><name sortKey="Ahued, A" uniqKey="Ahued A">A Ahued</name>
</author>
<author><name sortKey="Davoudi, B" uniqKey="Davoudi B">B Davoudi</name>
</author>
<author><name sortKey="Meza, R" uniqKey="Meza R">R Meza</name>
</author>
<author><name sortKey="Meyers, La" uniqKey="Meyers L">La Meyers</name>
</author>
<author><name sortKey="Skowronski, Dm" uniqKey="Skowronski D">DM Skowronski</name>
</author>
<author><name sortKey="Villase Or, I" uniqKey="Villase Or I">I Villaseñor</name>
</author>
<author><name sortKey="Galvan, F" uniqKey="Galvan F">F Galván</name>
</author>
<author><name sortKey="Cravioto, P" uniqKey="Cravioto P">P Cravioto</name>
</author>
<author><name sortKey="Earn, Djd" uniqKey="Earn D">DJD Earn</name>
</author>
<author><name sortKey="Dushoff, J" uniqKey="Dushoff J">J Dushoff</name>
</author>
<author><name sortKey="Fisman, D" uniqKey="Fisman D">D Fisman</name>
</author>
<author><name sortKey="Edmunds, Wj" uniqKey="Edmunds W">WJ Edmunds</name>
</author>
<author><name sortKey="Hupert, N" uniqKey="Hupert N">N Hupert</name>
</author>
<author><name sortKey="Scarpino, Sv" uniqKey="Scarpino S">SV Scarpino</name>
</author>
<author><name sortKey="Trujillo, J" uniqKey="Trujillo J">J Trujillo</name>
</author>
<author><name sortKey="Lutzow, M" uniqKey="Lutzow M">M Lutzow</name>
</author>
<author><name sortKey="Morales, J" uniqKey="Morales J">J Morales</name>
</author>
<author><name sortKey="Contreras, A" uniqKey="Contreras A">A Contreras</name>
</author>
<author><name sortKey="Chavez, C" uniqKey="Chavez C">C Chávez</name>
</author>
<author><name sortKey="Patrick, Dm" uniqKey="Patrick D">DM Patrick</name>
</author>
<author><name sortKey="Brunham, Rc" uniqKey="Brunham R">RC Brunham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, Lf" uniqKey="White L">LF White</name>
</author>
<author><name sortKey="Wallinga, J" uniqKey="Wallinga J">J Wallinga</name>
</author>
<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
<author><name sortKey="Pagano, M" uniqKey="Pagano M">M Pagano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Sugimoto, Jd" uniqKey="Sugimoto J">JD Sugimoto</name>
</author>
<author><name sortKey="Halloran, Me" uniqKey="Halloran M">ME Halloran</name>
</author>
<author><name sortKey="Basta, Ne" uniqKey="Basta N">NE Basta</name>
</author>
<author><name sortKey="Chao, Dl" uniqKey="Chao D">DL Chao</name>
</author>
<author><name sortKey="Matrajt, L" uniqKey="Matrajt L">L Matrajt</name>
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<author><name sortKey="Potter, G" uniqKey="Potter G">G Potter</name>
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<author><name sortKey="Kenah, E" uniqKey="Kenah E">E Kenah</name>
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</author>
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</author>
<author><name sortKey="Kosman, E" uniqKey="Kosman E">E Kosman</name>
</author>
</analytic>
</biblStruct>
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<author><name sortKey="Yan, G" uniqKey="Yan G">G Yan</name>
</author>
</analytic>
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</author>
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</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Hsieh, Yh" uniqKey="Hsieh Y">YH Hsieh</name>
</author>
<author><name sortKey="Ma, S" uniqKey="Ma S">S Ma</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Hsieh, Yh" uniqKey="Hsieh Y">YH Hsieh</name>
</author>
<author><name sortKey="Fisman, Dn" uniqKey="Fisman D">DN Fisman</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Wallace, J" uniqKey="Wallace J">J Wallace</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hsieh, Yh" uniqKey="Hsieh Y">YH Hsieh</name>
</author>
</analytic>
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</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Ghani, Ac" uniqKey="Ghani A">AC Ghani</name>
</author>
<author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">Ca Donnelly</name>
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<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name>
</author>
<author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name>
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<author><name sortKey="Lam, Th" uniqKey="Lam T">TH Lam</name>
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</author>
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<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Olsen, Sj" uniqKey="Olsen S">SJ Olsen</name>
</author>
<author><name sortKey="Doshi, S" uniqKey="Doshi S">S Doshi</name>
</author>
<author><name sortKey="Jackson, Ml" uniqKey="Jackson M">ML Jackson</name>
</author>
<author><name sortKey="Kennedy, Ed" uniqKey="Kennedy E">ED Kennedy</name>
</author>
<author><name sortKey="Kamimoto, L" uniqKey="Kamimoto L">L Kamimoto</name>
</author>
<author><name sortKey="Marchbanks, Tl" uniqKey="Marchbanks T">TL Marchbanks</name>
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<author><name sortKey="Morgan, Ow" uniqKey="Morgan O">OW Morgan</name>
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<author><name sortKey="Patel, M" uniqKey="Patel M">M Patel</name>
</author>
<author><name sortKey="Swerdlow, Dl" uniqKey="Swerdlow D">DL Swerdlow</name>
</author>
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</author>
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</biblStruct>
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</author>
</analytic>
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</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Meijer, A" uniqKey="Meijer A">A Meijer</name>
</author>
<author><name sortKey="Timen, A" uniqKey="Timen A">A Timen</name>
</author>
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</author>
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</author>
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</author>
<author><name sortKey="Yan, P" uniqKey="Yan P">P Yan</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Moghadas, S" uniqKey="Moghadas S">S Moghadas</name>
</author>
<author><name sortKey="Buckeridge, D" uniqKey="Buckeridge D">D Buckeridge</name>
</author>
<author><name sortKey="Pourbohloul, B" uniqKey="Pourbohloul B">B Pourbohloul</name>
</author>
<author><name sortKey="Fisman, Dn" uniqKey="Fisman D">DN Fisman</name>
</author>
</analytic>
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</author>
<author><name sortKey="Merler, S" uniqKey="Merler S">S Merler</name>
</author>
<author><name sortKey="Pugliese, A" uniqKey="Pugliese A">a Pugliese</name>
</author>
<author><name sortKey="Rizzo, C" uniqKey="Rizzo C">C Rizzo</name>
</author>
</analytic>
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</author>
<author><name sortKey="Kelso, Jk" uniqKey="Kelso J">JK Kelso</name>
</author>
<author><name sortKey="Milne, Gj" uniqKey="Milne G">GJ Milne</name>
</author>
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</author>
<author><name sortKey="Fleming, D" uniqKey="Fleming D">D Fleming</name>
</author>
<author><name sortKey="Handel, A" uniqKey="Handel A">A Handel</name>
</author>
<author><name sortKey="Miller, Ma" uniqKey="Miller M">Ma Miller</name>
</author>
<author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
</analytic>
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</author>
<author><name sortKey="Yan, P" uniqKey="Yan P">P Yan</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Tamblyn Df, Se" uniqKey="Tamblyn Df S">SE Tamblyn DF</name>
</author>
</analytic>
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</author>
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</author>
<author><name sortKey="Greer, Al" uniqKey="Greer A">AL Greer</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Moghadas, Sm" uniqKey="Moghadas S">SM Moghadas</name>
</author>
</analytic>
</biblStruct>
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</author>
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</author>
<author><name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name>
</author>
<author><name sortKey="Oseroff, C" uniqKey="Oseroff C">C Oseroff</name>
</author>
<author><name sortKey="Vaughan, K" uniqKey="Vaughan K">K Vaughan</name>
</author>
<author><name sortKey="Salimi, N" uniqKey="Salimi N">N Salimi</name>
</author>
<author><name sortKey="Vita, R" uniqKey="Vita R">R Vita</name>
</author>
<author><name sortKey="Ponomarenko, J" uniqKey="Ponomarenko J">J Ponomarenko</name>
</author>
<author><name sortKey="Scheuermann, Rh" uniqKey="Scheuermann R">RH Scheuermann</name>
</author>
<author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name>
</author>
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</author>
</analytic>
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</author>
<author><name sortKey="Moghadas, Sm" uniqKey="Moghadas S">SM Moghadas</name>
</author>
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</author>
<author><name sortKey="Duvvuri, B" uniqKey="Duvvuri B">B Duvvuri</name>
</author>
<author><name sortKey="Heffernan, Jm" uniqKey="Heffernan J">JM Heffernan</name>
</author>
<author><name sortKey="Fisman, Dn" uniqKey="Fisman D">DN Fisman</name>
</author>
<author><name sortKey="Wu, Ge" uniqKey="Wu G">GE Wu</name>
</author>
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</author>
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   |texte=   Variability in transmissibility of the 2009 H1N1 pandemic in Canadian communities
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Variability in transmissibility of the 2009 H1N1 pandemic in Canadian communities

Variability in transmissibility of the 2009 H1N1 pandemic in Canadian communities

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